[HTML][HTML] Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load
MA Meier, D Calabrese, A Suslov, LM Terracciano… - Journal of …, 2021 - Elsevier
Background & Aims Loss of serum HBsAg is a hallmark of spontaneous and therapy
induced resolution of HBV infection, since it generally reflects a profound decrease in viral
replication. However, integrated HBV DNA can contribute to HBsAg expression independent
of viral replication. The relative contributions of these sources of HBsAg are not well
understood. Specifically, it is not known whether actively transcribed HBV integration could
spread throughout the entire liver. Methods The relative distribution of HBsAg and HBV RNA …
induced resolution of HBV infection, since it generally reflects a profound decrease in viral
replication. However, integrated HBV DNA can contribute to HBsAg expression independent
of viral replication. The relative contributions of these sources of HBsAg are not well
understood. Specifically, it is not known whether actively transcribed HBV integration could
spread throughout the entire liver. Methods The relative distribution of HBsAg and HBV RNA …