[HTML][HTML] The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1
K Janes, JW Little, C Li, L Bryant, C Chen… - Journal of Biological …, 2014 - ASBMB
The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate.
Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic
ceramide in their anticancer effects. The ceramide-to-S1P pathway is also implicated in the
development of pain, raising the intriguing possibility that these sphingolipids may contribute
to chemotherapy-induced painful peripheral neuropathy, which can be a critical dose-
limiting side effect of many widely used chemotherapeutic agents. We demonstrate that the …
Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic
ceramide in their anticancer effects. The ceramide-to-S1P pathway is also implicated in the
development of pain, raising the intriguing possibility that these sphingolipids may contribute
to chemotherapy-induced painful peripheral neuropathy, which can be a critical dose-
limiting side effect of many widely used chemotherapeutic agents. We demonstrate that the …