Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3
KO Kisich, CW Carspecken, S Fiéve… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Individuals with atopic dermatitis (AD) have frequent colonization and
infection with Staphylococcus aureus. Rapid elimination of S aureus depends on constitutive
synthesis and mobilization of human β-defensin-3 (HBD-3). OBJECTIVE: To determine
whether keratinocytes in AD, compared with normal, skin are less able to kill S aureus
rapidly, and to assess the potential role that abnormally low mobilization of HBD-3 onto S
aureus has in this process. METHODS: Skin samples from 10 normal individuals and 10 …
infection with Staphylococcus aureus. Rapid elimination of S aureus depends on constitutive
synthesis and mobilization of human β-defensin-3 (HBD-3). OBJECTIVE: To determine
whether keratinocytes in AD, compared with normal, skin are less able to kill S aureus
rapidly, and to assess the potential role that abnormally low mobilization of HBD-3 onto S
aureus has in this process. METHODS: Skin samples from 10 normal individuals and 10 …