Inducible targeting of cDCs and their subsets in vivo
J Loschko, GJ Rieke, HA Schreiber… - Journal of …, 2016 - Elsevier
Conventional dendritic cells (cDCs) are essential immune cells linking the innate and
adaptive immune system. cDC depletion in mice is an important method to study the function
of these cells in vivo. Here we report an inducible in vivo system for cDC depletion in which
excision of a loxP flanked Stop signal enables expression of the human diphtheria toxin
receptor (DTR) under the control of Zbtb46 (zDC lSlDTR). cDCs can be specifically depleted
by combining zDC lSlDTR mice with a Csf1r Cre driver line. In addition, we show that zDC …
adaptive immune system. cDC depletion in mice is an important method to study the function
of these cells in vivo. Here we report an inducible in vivo system for cDC depletion in which
excision of a loxP flanked Stop signal enables expression of the human diphtheria toxin
receptor (DTR) under the control of Zbtb46 (zDC lSlDTR). cDCs can be specifically depleted
by combining zDC lSlDTR mice with a Csf1r Cre driver line. In addition, we show that zDC …