Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history
P Fitzgerald-Bocarsly, J Dai, S Singh - Cytokine & growth factor reviews, 2008 - Elsevier
It has been 50 years since the initial descriptions of what are now known as plasmacytoid
dendritic cells (pDC) and type I IFN. pDC, which are infrequent cells found in the peripheral
blood and lymphoid organs, are the most potent producers of type I and type III IFNs in the
body. pDC produce IFN-α in response to both DNA and RNA enveloped viruses by virtue of
their ribonucleic acids signaling in the endosome through TLR9 and TLR7, respectively.
This stimulation, which also occurs with DNA or RNA-containing immune complexes and …
dendritic cells (pDC) and type I IFN. pDC, which are infrequent cells found in the peripheral
blood and lymphoid organs, are the most potent producers of type I and type III IFNs in the
body. pDC produce IFN-α in response to both DNA and RNA enveloped viruses by virtue of
their ribonucleic acids signaling in the endosome through TLR9 and TLR7, respectively.
This stimulation, which also occurs with DNA or RNA-containing immune complexes and …