The shift in the balance between the inhibition and the excitation in favor of the latter is a
major mechanism of the evolvement of epileptic seizures. On the neurotransmitter level two
major players contribute to such misbalance: an inhibitory transmitter γ-aminobutyric acid,
and an excitatory amino acid glutamate. Neuropeptides are powerful modulators of classical
neurotransmitters, and thus represent an intriguing tool for restoring the balance between
the inhibition and the excitation, through either blocking or activating peptide receptors …