[HTML][HTML] JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
A Yadav, A Kalita, S Dhillon, K Banerjee - Journal of Biological Chemistry, 2005 - ASBMB
Janus kinases (JAK) and signal transducers and activator of transcription (STAT) proteins
are activated in response to many cytokines and growth factors and are well studied in the
immune system. This study was conducted to examine the role of the JAK/STAT pathway in
neurons in response to tumor necrosis factor-α (TNFα) and insulin-like growth factor-1 (IGF-
1), which play a major role during neurodegeneration, and to study their effect on expression
of suppressors of cytokine signaling 3 (SOCS-3), belonging to the novel family of feedback …
are activated in response to many cytokines and growth factors and are well studied in the
immune system. This study was conducted to examine the role of the JAK/STAT pathway in
neurons in response to tumor necrosis factor-α (TNFα) and insulin-like growth factor-1 (IGF-
1), which play a major role during neurodegeneration, and to study their effect on expression
of suppressors of cytokine signaling 3 (SOCS-3), belonging to the novel family of feedback …