The effects of healthy aging on the kidney, and how these effects intersect with
superimposed diseases, are highly relevant in the context of the population's increasing
longevity. Age-associated changes to podocytes, which are terminally differentiated
glomerular epithelial cells, adversely affect kidney health. This review discusses the
molecular and cellular mechanisms underlying podocyte aging, how these mechanisms
might be augmented by disease in the aged kidney, and approaches to mitigate progressive …