Comparison of mice with accelerated aging caused by distinct mechanisms

AU Gurkar, LJ Niedernhofer - Experimental gerontology, 2015 - Elsevier
Aging is the primary risk factor for numerous chronic, debilitating diseases. These diseases
impact quality of life of the elderly and consume a large portion of health care costs. The cost
of age-related diseases will only increase as the world's population continues to live longer.
Thus it would be advantageous to consider aging itself as a therapeutic target, potentially
stemming multiple age-related diseases simultaneously. While logical, this is extremely
challenging as the molecular mechanisms that drive aging are still unknown. Furthermore …