Formation and biological consequences of 5-Formylcytosine in genomic DNA
Y Zhang, C Zhou - DNA repair, 2019 - Elsevier
Formyl-2′-deoxycytidine (5fdC) is a naturally occurring nucleobase that is broadly
distributed in genomic DNA. 5fdC is produced via the oxidation of 5-methylcytosine (5mdC)
by ten-eleven translocation enzyme (TET) and can be further converted to 5-
carboxylcytosine (5cadC) by TET. Both 5fdC and 5cadC can be restored to dC by TDG-
mediated base excision repair and direct deformylation/decarboxylation. Thus, 5fdC is
considered an intermediate in the TET-mediated DNA demethylation pathway. 5fdC also …
distributed in genomic DNA. 5fdC is produced via the oxidation of 5-methylcytosine (5mdC)
by ten-eleven translocation enzyme (TET) and can be further converted to 5-
carboxylcytosine (5cadC) by TET. Both 5fdC and 5cadC can be restored to dC by TDG-
mediated base excision repair and direct deformylation/decarboxylation. Thus, 5fdC is
considered an intermediate in the TET-mediated DNA demethylation pathway. 5fdC also …