mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
Nature neuroscience, 2018•nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be
necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-
LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD
and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient
mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2)
activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors …
necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-
LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD
and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient
mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2)
activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors …
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.
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