Coding of facial expressions of pain in the laboratory mouse
DJ Langford, AL Bailey, ML Chanda, SE Clarke… - Nature …, 2010 - nature.com
DJ Langford, AL Bailey, ML Chanda, SE Clarke, TE Drummond, S Echols, S Glick, J Ingrao…
Nature methods, 2010•nature.comFacial expression is widely used as a measure of pain in infants; whether nonhuman
animals display such pain expressions has never been systematically assessed. We
developed the mouse grimace scale (MGS), a standardized behavioral coding system with
high accuracy and reliability; assays involving noxious stimuli of moderate duration are
accompanied by facial expressions of pain. This measure of spontaneously emitted pain
may provide insight into the subjective pain experience of mice.
animals display such pain expressions has never been systematically assessed. We
developed the mouse grimace scale (MGS), a standardized behavioral coding system with
high accuracy and reliability; assays involving noxious stimuli of moderate duration are
accompanied by facial expressions of pain. This measure of spontaneously emitted pain
may provide insight into the subjective pain experience of mice.
Abstract
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.
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