[HTML][HTML] Tissue factor upregulation is associated with SARS‐CoV‐2 in the lungs of COVID‐19 patients

S Subrahmanian, A Borczuk, S Salvatore… - Journal of Thrombosis …, 2021 - Elsevier
Background A substantial proportion of patients infected with severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) develop severe/critical coronavirus disease 2019
(COVID‐19) characterized by acute respiratory distress syndrome (ARDS) with thrombosis.
Objectives We tested the hypothesis that SARS‐CoV‐2‐‐induced upregulation of tissue
factor (TF) expression may be responsible for thrombus formation in COVID‐19. Methods
We compared autopsy lung tissues from 11 patients with COVID‐19‐‐associated ARDS with …