129/SvJ mice have mutated CD23 and hyper IgE
JW Ford, JL Sturgill, DH Conrad - Cellular immunology, 2009 - Elsevier
CD23, the low affinity IgE receptor, is hypothesized to function as a negative regulator of IgE
production. Upon discovering reduced CD23 surface levels in 129/SvJ inbred mice, we
sought to further investigate 129/SvJ CD23 and to examine its influence on IgE levels. Five
amino acid substitutions were found in 129/SvJ CD23. Identical mutations were also
observed in CD23 from New Zealand Black and 129P1/ReJ mice. 129/SvJ B cells
proliferated more rapidly than those from BALB/c after stimulation with IL-4 and CD40 ligand …
production. Upon discovering reduced CD23 surface levels in 129/SvJ inbred mice, we
sought to further investigate 129/SvJ CD23 and to examine its influence on IgE levels. Five
amino acid substitutions were found in 129/SvJ CD23. Identical mutations were also
observed in CD23 from New Zealand Black and 129P1/ReJ mice. 129/SvJ B cells
proliferated more rapidly than those from BALB/c after stimulation with IL-4 and CD40 ligand …