[HTML][HTML] Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
KT Kim, HH Choi, MO Steinmetz, B Maco… - Journal of Biological …, 2005 - ASBMB
Angiopoietin-1 (Ang1) is an essential molecule for blood vessel formation; however, little is
known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine
kinase with immunoglobulin and epidermal growth factor homology domain-2′). In this
study, we generated several Ang1 and angiopoietin-2 (Ang2) variants to define the role of
the superclustering and oligomerization domains of the Ang1 protein. Then we analyzed the
molecular structure of the variants with SDS-PAGE and rotary metal-shadowing transmission …
known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine
kinase with immunoglobulin and epidermal growth factor homology domain-2′). In this
study, we generated several Ang1 and angiopoietin-2 (Ang2) variants to define the role of
the superclustering and oligomerization domains of the Ang1 protein. Then we analyzed the
molecular structure of the variants with SDS-PAGE and rotary metal-shadowing transmission …