[HTML][HTML] Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration …
P Saraon, N Musrap, D Cretu, GS Karagiannis… - Journal of Biological …, 2012 - ASBMB
Androgen deprivation constitutes the principal therapy for advanced and metastatic prostate
cancers. However, this therapeutic intervention usually results in the transition to a more
aggressive androgen-independent prostate cancer. The elucidation of molecular alterations
during the progression to androgen independence is an integral step toward discovering
more effective targeted therapies. With respect to identifying crucial mediators of this
transition, we compared the proteomes of androgen-independent (PC3, DU145, PPC1 …
cancers. However, this therapeutic intervention usually results in the transition to a more
aggressive androgen-independent prostate cancer. The elucidation of molecular alterations
during the progression to androgen independence is an integral step toward discovering
more effective targeted therapies. With respect to identifying crucial mediators of this
transition, we compared the proteomes of androgen-independent (PC3, DU145, PPC1 …