Postulated boundaries and differential fate in the developing rostral hindbrain

P Aroca, L Puelles - Brain research reviews, 2005 - Elsevier
The vertebrate brain is progressively regionalized during development in a process whereby
a precise spatio-temporal arrangement of gene expression patterns and resulting
intercellular and intracellular signals drive patterning, growth, morphogenesis, and final
fates, thus producing ordered species-specific differentiation of each territory within a shared
morphotype. Before genetic and molecular biology tools started to be used to uncover the
underlying mechanisms that control morphogenesis, knowledge on brain development …