Subclass IgG to motor gangliosides related to infection and clinical course in Guillain–Barré syndrome
BC Jacobs, M Koga, W van Rijs, K Geleijns… - Journal of …, 2008 - Elsevier
In 176 patients with Guillain–Barré syndrome the subclass and cross-reactivity of serum IgG
antibodies to motor gangliosides was related to preceding infections and clinical
phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies
was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C.
jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3
antibodies was related to upper respiratory tract infections, cross-reactive antibodies to …
antibodies to motor gangliosides was related to preceding infections and clinical
phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies
was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C.
jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3
antibodies was related to upper respiratory tract infections, cross-reactive antibodies to …