Major urinary protein (MUP) 1 is a lipocalin family member abundantly secreted into the
circulation by the liver. MUP1 binds to lipophilic pheromones and is excreted in urine.
Urinary MUP1/pheromone complexes mediate chemical communication in rodents.
However, it is unclear whether circulatory MUP1 has additional physiological functions. Here
we show that MUP1 regulates glucose and lipid metabolism. MUP1 expression was
markedly reduced in both genetic and dietary fat-induced obesity and diabetes. Mice were …