[HTML][HTML] FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in …
C Kibbe, J Chen, G Xu, G Jing, A Shalev - Journal of Biological Chemistry, 2013 - ASBMB
Thioredoxin-interacting protein (TXNIP) has emerged as an important factor in pancreatic
beta cell biology, and tight regulation of TXNIP levels is necessary for beta cell survival.
However, the mechanisms regulating TXNIP expression have only started to be elucidated.
The forkhead boxO1 transcription factor (FOXO1) has been reported to up-regulate TXNIP
expression in neurons and endothelial cells but to down-regulate TXNIP in liver, and the
effects on beta cells have remained unknown. We now have found that FOXO1 binds to the …
beta cell biology, and tight regulation of TXNIP levels is necessary for beta cell survival.
However, the mechanisms regulating TXNIP expression have only started to be elucidated.
The forkhead boxO1 transcription factor (FOXO1) has been reported to up-regulate TXNIP
expression in neurons and endothelial cells but to down-regulate TXNIP in liver, and the
effects on beta cells have remained unknown. We now have found that FOXO1 binds to the …