The role of cellular senescence in ageing of the placenta

LS Cox, C Redman - Placenta, 2017 - Elsevier
Aberrant placental ageing is implicated in a high percentage of birth complications, stillbirths
and neonatal deaths. Understanding how this complex organ is established and maintained
for the 9–10 months of pregnancy and then how and why it undergoes the physiological
changes that result in labour at term is therefore of enormous clinical importance. In this
review, we assess the evidence that placental ageing results from cellular senescence, a
state of terminal proliferation arrest accompanied by characteristic morphological and …