BAX and BAK at the gates of innate immunity
L Galluzzi, C Vanpouille-Box - Trends in Cell Biology, 2018 - cell.com
Trends in Cell Biology, 2018•cell.com
Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access
the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological
conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells
to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic
signaling and innate immunity control.
the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological
conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells
to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic
signaling and innate immunity control.
Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.
cell.com