Adhesion and migration of polymorphonuclear leukocytes across human brain microvessel endothelial cells are differentially regulated by endothelial cell adhesion …
D Wong, R Prameya, K Dorovini-Zis - Journal of neuroimmunology, 2007 - Elsevier
The mechanisms by which polymorphonuclear leukocytes (PMN) cross the human blood–
brain barrier have not been fully elucidated. Using a well characterized in vitro model of the
human BBB, we examined the role of endothelial cell adhesion molecules on the adhesion
and transendothelial migration of PMN across primary cultures of human brain microvessel
endothelial cells (HBMEC). A small number of PMN (0.06%) adhered to unstimulated
HBMEC, and the basal adhesion was not affected by anti-adhesion molecule antibodies …
brain barrier have not been fully elucidated. Using a well characterized in vitro model of the
human BBB, we examined the role of endothelial cell adhesion molecules on the adhesion
and transendothelial migration of PMN across primary cultures of human brain microvessel
endothelial cells (HBMEC). A small number of PMN (0.06%) adhered to unstimulated
HBMEC, and the basal adhesion was not affected by anti-adhesion molecule antibodies …