[HTML][HTML] Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown …
P Siri, N Candela, YL Zhang, C Ko, S Eusufzai… - Journal of Biological …, 2001 - ASBMB
A mouse model of insulin resistance and its associated dyslipidemia was generated by
crossing mice expressing human apolipoprotein B (apoB) with mice lacking only brown
adipose tissue (BATless). On a high fat diet, male apoB/BATless mice became obese,
hypercholesterolemic, hypertriglyceridemic, and hyperinsulinemic compared with control
apoB mice. Fast performance liquid chromatography revealed increased triglyceride
concentrations in intermediate density lipoprotein/low density lipoprotein (LDL) and reduced …
crossing mice expressing human apolipoprotein B (apoB) with mice lacking only brown
adipose tissue (BATless). On a high fat diet, male apoB/BATless mice became obese,
hypercholesterolemic, hypertriglyceridemic, and hyperinsulinemic compared with control
apoB mice. Fast performance liquid chromatography revealed increased triglyceride
concentrations in intermediate density lipoprotein/low density lipoprotein (LDL) and reduced …