[HTML][HTML] Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER
W Liao, TY Hui, SG Young, RA Davis - Journal of lipid research, 2003 - ASBMB
Microsomal triglyceride transfer protein (MTP) is an intraluminal protein in the endoplasmic
reticulum (ER) that is essential for the assembly of apolipoprotein B (apoB)-containing
lipoproteins. In this study, we examine how the livers of mice respond to two distinct methods
of blocking MTP function: Cre-mediated disruption of the gene for MTP and chemical
inhibition of MTP activity. Blocking MTP significantly reduced plasma levels of triglycerides,
cholesterol, and apoB-containing lipoproteins in both wild-type C57BL/6 and LDL receptor …
reticulum (ER) that is essential for the assembly of apolipoprotein B (apoB)-containing
lipoproteins. In this study, we examine how the livers of mice respond to two distinct methods
of blocking MTP function: Cre-mediated disruption of the gene for MTP and chemical
inhibition of MTP activity. Blocking MTP significantly reduced plasma levels of triglycerides,
cholesterol, and apoB-containing lipoproteins in both wild-type C57BL/6 and LDL receptor …