[HTML][HTML] Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance: evidence for enhanced lipoprotein assembly, reduced intracellular …
C Taghibiglou, A Carpentier, SC Van Iderstine… - Journal of Biological …, 2000 - ASBMB
A novel animal model of insulin resistance, the fructose-fed Syrian golden hamster, was
employed to investigate the mechanisms mediating the overproduction of very low density
lipoprotein (VLDL) in the insulin resistant state. Fructose feeding for a 2-week period
induced significant hypertriglyceridemia and hyperinsulinemia, and the development of
whole body insulin resistance was documented using the euglycemic-hyperinsulinemic
clamp technique. In vivo Triton WR-1339 studies showed evidence of VLDL-apoB …
employed to investigate the mechanisms mediating the overproduction of very low density
lipoprotein (VLDL) in the insulin resistant state. Fructose feeding for a 2-week period
induced significant hypertriglyceridemia and hyperinsulinemia, and the development of
whole body insulin resistance was documented using the euglycemic-hyperinsulinemic
clamp technique. In vivo Triton WR-1339 studies showed evidence of VLDL-apoB …