[HTML][HTML] Differential effects of gut-homing molecules CC chemokine receptor 9 and integrin-β7 during acute graft-versus-host disease of the liver
A Schreder, GL Moschovakis, S Halle, J Schlue… - Biology of Blood and …, 2015 - Elsevier
A Schreder, GL Moschovakis, S Halle, J Schlue, CW Lee, A Schippers, S David, G Bernhardt…
Biology of Blood and Marrow Transplantation, 2015•ElsevierHoming of allogeneic donor T cells to recipient tissue is imperative for the development of
acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this
study we show that alteration of T cell homing due to integrin-β7 deficiency on T cells or its
ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental
GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing
but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly …
acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this
study we show that alteration of T cell homing due to integrin-β7 deficiency on T cells or its
ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental
GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing
but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly …
Abstract
Homing of allogeneic donor T cells to recipient tissue is imperative for the development of acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this study we show that alteration of T cell homing due to integrin-β7 deficiency on T cells or its ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly expressed in hepatic murine GVHD as well as in patients with active liver GVHD. However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue.
Elsevier