Regulation of mitochondrial biogenesis through TFAM–mitochondrial DNA interactions: useful insights from aging and calorie restriction studies
A Picca, AMS Lezza - Mitochondrion, 2015 - Elsevier
Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy
demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA
and interactions between TFAM and mtDNA participate to regulation of mitochondrial
biogenesis. Such interactions are modulated through different mechanisms: regulation of
TFAM expression and turnover, modulation of TFAM binding activity to mtDNA through post-
translational modifications and differential affinity of TFAM, occurrence of TFAM sliding on …
demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA
and interactions between TFAM and mtDNA participate to regulation of mitochondrial
biogenesis. Such interactions are modulated through different mechanisms: regulation of
TFAM expression and turnover, modulation of TFAM binding activity to mtDNA through post-
translational modifications and differential affinity of TFAM, occurrence of TFAM sliding on …