Aberrant mTOR activation in senescence and aging: a mitochondrial stress response?
T Nacarelli, A Azar, C Sell - Experimental gerontology, 2015 - Elsevier
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or
ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings.
Evidence of elevated mTOR activity has been reported in the heart and muscle tissue in
aged mice and humans, mouse models of progeria, and senescent human fibroblasts. We
explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway
may represent a ROS-mediated response to mitochondrial stress leading to the activation of …
ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings.
Evidence of elevated mTOR activity has been reported in the heart and muscle tissue in
aged mice and humans, mouse models of progeria, and senescent human fibroblasts. We
explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway
may represent a ROS-mediated response to mitochondrial stress leading to the activation of …
