Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5
M Wan, X Hua, J Su, D Thiagarajan, AG Frostegård… - Atherosclerosis, 2014 - Elsevier
Objective Cardiolipin (CL) is a phospholipid with an unusual dimeric structure containing
four double-bonds and is easily oxidized. CL is present in mitochondria. Here we explored
potential pro-inflammatory properties implicated in cardiovascular disease (CVD): activation
of endothelial cells, 5-lipoxygenase (5-LOX) and leukotriene B4 (LTB4), by oxidized CL
(oxCL) and inhibitory effects of Annexin A5, an antithrombotic and antiinflammatory plasma
protein. Methods In monocytes/macrophages and neutrophils, calcium mobilization was …
four double-bonds and is easily oxidized. CL is present in mitochondria. Here we explored
potential pro-inflammatory properties implicated in cardiovascular disease (CVD): activation
of endothelial cells, 5-lipoxygenase (5-LOX) and leukotriene B4 (LTB4), by oxidized CL
(oxCL) and inhibitory effects of Annexin A5, an antithrombotic and antiinflammatory plasma
protein. Methods In monocytes/macrophages and neutrophils, calcium mobilization was …