[HTML][HTML] Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes
L Böttinger, S Oeljeklaus, B Guiard, S Rospert… - Journal of Biological …, 2015 - ASBMB
Mitochondrial Hsp70 (mtHsp70) mediates essential functions for mitochondrial biogenesis,
like import and folding of proteins. In these processes, the chaperone cooperates with
cochaperones, the presequence translocase, and other chaperone systems. The
chaperonin Hsp60, together with its cofactor Hsp10, catalyzes folding of a subset of
mtHsp70 client proteins. Hsp60 forms heptameric ring structures that provide a cavity for
protein folding. How the Hsp60 rings are assembled is poorly understood. In a …
like import and folding of proteins. In these processes, the chaperone cooperates with
cochaperones, the presequence translocase, and other chaperone systems. The
chaperonin Hsp60, together with its cofactor Hsp10, catalyzes folding of a subset of
mtHsp70 client proteins. Hsp60 forms heptameric ring structures that provide a cavity for
protein folding. How the Hsp60 rings are assembled is poorly understood. In a …