[HTML][HTML] IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation
K Kawai, M Uchiyama, J Hester, F Issa - American Journal of …, 2021 - Elsevier
Regulatory T cells (Tregs) are crucial mediators of immune homeostasis with the ability to
modulate allogeneic response and control transplant rejection. Although Treg-based cell
therapies have shown immense promise, methods to optimize current strategies are critical
for successful implementation within the clinic. IL-33 is a cytokine with pleiotropic properties
and effects on Treg function and development. In this study, we explored the unique
properties of Treg populations activated through the IL-33/ST2 pathway, aiming to exploit …
modulate allogeneic response and control transplant rejection. Although Treg-based cell
therapies have shown immense promise, methods to optimize current strategies are critical
for successful implementation within the clinic. IL-33 is a cytokine with pleiotropic properties
and effects on Treg function and development. In this study, we explored the unique
properties of Treg populations activated through the IL-33/ST2 pathway, aiming to exploit …