Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
D Focosi, M Franchini - Transfusion Clinique et Biologique, 2021 - Elsevier
Pathogen reduction technologies (PRT) have been recommended by many regulatory
authorities to minimize the residual risk of transfusion-transmitted infections associated with
COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are
nowadays well proven, there is theoretical concern that PRT could impact efficacy of
convalescent plasma by altering concentration and/or function of the neutralizing antibodies
(nAb). We review here the evidence supporting a lack of significant detrimental effect from …
authorities to minimize the residual risk of transfusion-transmitted infections associated with
COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are
nowadays well proven, there is theoretical concern that PRT could impact efficacy of
convalescent plasma by altering concentration and/or function of the neutralizing antibodies
(nAb). We review here the evidence supporting a lack of significant detrimental effect from …