[HTML][HTML] The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis
P Hundehege, M Cerina, S Eichler… - Neural regeneration …, 2019 - journals.lww.com
Autoimmune diseases of the central nervous system (CNS) like multiple sclerosis (MS) are
characterized by inflammation and demyelinated lesions in white and grey matter regions.
While inflammation is present at all stages of MS, it is more pronounced in the relapsing
forms of the disease, whereas progressive MS (PMS) shows significant neuroaxonal
damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial
in patients with relapsing MS have limited success in PMS. BAF312 (siponimod) is a novel …
characterized by inflammation and demyelinated lesions in white and grey matter regions.
While inflammation is present at all stages of MS, it is more pronounced in the relapsing
forms of the disease, whereas progressive MS (PMS) shows significant neuroaxonal
damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial
in patients with relapsing MS have limited success in PMS. BAF312 (siponimod) is a novel …