Importance Prospective cohorts in North America, Europe, and Asia show consistent inverse
associations between coffee drinking and mortality, including deaths from cardiovascular
disease and some cancers. However, concerns about coffee, particularly among people with
common genetic polymorphisms affecting caffeine metabolism and among those drinking
more than 5 cups per day, remain. Objective To evaluate associations of coffee drinking with
mortality by genetic caffeine metabolism score. Design, Setting, and Participants The UK …