PI3K pathway effectors pAKT and FOXO1 as novel markers of endometrioid intraepithelial neoplasia
AL Strickland, G Rivera, E Lucas, G John… - International Journal …, 2019 - journals.lww.com
The diagnosis of endometrioid intraepithelial neoplasia (EIN) is challenging owing to limited
sampling, hormonal status, and other confounding histologic variables. Markers such as
PTEN or PAX2 can delineate EIN in some cases, but are not wholly reliable. Clearly, new
markers of EIN are needed. We explored several potential markers of EIN based rationally
on molecular pathways most frequently misregulated in endometrial cancer: the 3-
phosphoinositide kinase (PI3K)/AKT, β-catenin, and mismatch repair pathways. We studied …
sampling, hormonal status, and other confounding histologic variables. Markers such as
PTEN or PAX2 can delineate EIN in some cases, but are not wholly reliable. Clearly, new
markers of EIN are needed. We explored several potential markers of EIN based rationally
on molecular pathways most frequently misregulated in endometrial cancer: the 3-
phosphoinositide kinase (PI3K)/AKT, β-catenin, and mismatch repair pathways. We studied …