[HTML][HTML] Wnt/β-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3

M Basu, SS Roy - Journal of Biological Chemistry, 2013 - ASBMB
Pituitary homeobox-2 (PITX2) plays a substantial role in the development of pituitary, heart,
and brain. Although the role of PITX2 isoforms in embryonic development has been
extensively studied, its possible involvement in regulating the Wnt signaling pathway has not
been reported. Because the Wnt pathway is strongly involved in ovarian development and
cancer, we focused on the possible association between PITX2 and Wnt pathway in ovarian
carcinoma cells. Remarkably, we found that PITX2 interacts and regulates WNT2/5A/9A/6/2B …