Dangers within: DAMP responses to damage and cell death in kidney disease
DL Rosin, MD Okusa - Journal of the American Society of …, 2011 - journals.lww.com
The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern
recognition receptors. A classic example is septic shock where Toll receptor 4 recognizes
PAMPs. Although well accepted, this concept does not explain the activation of innate
immunity and inflammation occurs with transplantation, autoimmunity, or trauma.
Increasingly recognized is that endogenous molecules released by dying cells (damage …
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern
recognition receptors. A classic example is septic shock where Toll receptor 4 recognizes
PAMPs. Although well accepted, this concept does not explain the activation of innate
immunity and inflammation occurs with transplantation, autoimmunity, or trauma.
Increasingly recognized is that endogenous molecules released by dying cells (damage …