[HTML][HTML] Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3 (PFKFB3) gene: its possible role in the …
A Minchenko, I Leshchinsky, I Opentanova… - Journal of Biological …, 2002 - ASBMB
One of the key mediators of the hypoxic response in animal cells is the hypoxia-inducible
transcription factor-1 (HIF-1) complex, in which the α-subunit is highly susceptible to oxygen-
dependent degradation. The hypoxic response is manifested in many pathophysiological
processes such as tumor growth and metastasis. During hypoxia, cells shift to a primarily
glycolytic metabolic mode for their energetic needs. This is also manifested in the HIF-1-
dependent up-regulation of many glycolytic genes. Paradoxically, tumor cells growing under …
transcription factor-1 (HIF-1) complex, in which the α-subunit is highly susceptible to oxygen-
dependent degradation. The hypoxic response is manifested in many pathophysiological
processes such as tumor growth and metastasis. During hypoxia, cells shift to a primarily
glycolytic metabolic mode for their energetic needs. This is also manifested in the HIF-1-
dependent up-regulation of many glycolytic genes. Paradoxically, tumor cells growing under …