Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing
In congenital Chuvash polycythemia (CP), VHL R200W homozygosity leads to elevated
hypoxia inducible factor (HIF) levels at normoxia. CP is often treated by phlebotomy resulting
in iron deficiency, permitting us to examine the separate and synergistic effects of iron
deficiency and HIF signaling on gene expression. We compared peripheral blood
mononuclear cell gene expression profiles of eight VHL R200W homozygotes with 17
wildtype individuals with normal iron status and found 812 up-regulated and 2120 down …
hypoxia inducible factor (HIF) levels at normoxia. CP is often treated by phlebotomy resulting
in iron deficiency, permitting us to examine the separate and synergistic effects of iron
deficiency and HIF signaling on gene expression. We compared peripheral blood
mononuclear cell gene expression profiles of eight VHL R200W homozygotes with 17
wildtype individuals with normal iron status and found 812 up-regulated and 2120 down …