[HTML][HTML] Nonhomologous DNA end-joining for repair of DNA double-strand breaks
NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of
the S and G 2 phases. NHEJ relies on Ku to thread onto DNA termini and thereby improve
the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ),
a nuclease (the Artemis· DNA-PKcs complex), and a ligase (XLF· XRCC4· Lig4 complex).
Each of the enzymatic components is distinctive for its versatility in acting on diverse …
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of
the S and G 2 phases. NHEJ relies on Ku to thread onto DNA termini and thereby improve
the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ),
a nuclease (the Artemis· DNA-PKcs complex), and a ligase (XLF· XRCC4· Lig4 complex).
Each of the enzymatic components is distinctive for its versatility in acting on diverse …