Regulatory signal transduction pathways for class IIa histone deacetylases
M Parra, E Verdin - Current opinion in pharmacology, 2010 - Elsevier
The class IIa histone deacetylases (HDACs), HDAC4, 5, 7, and 9, have crucial roles in the
development of the immune system and other organs, including brain, heart, and muscle. In
addition to their catalytic domain, they are characterized by a large amino-terminal
extension. The amino-terminal domain is subject to reversible phosphorylation, which
controls their nucleo-cytoplasmic distribution. Unphosphorylated, class IIa HDACs remain in
the nucleus, bound to chromatin, and repress transcription. Upon phosphorylation, they …
development of the immune system and other organs, including brain, heart, and muscle. In
addition to their catalytic domain, they are characterized by a large amino-terminal
extension. The amino-terminal domain is subject to reversible phosphorylation, which
controls their nucleo-cytoplasmic distribution. Unphosphorylated, class IIa HDACs remain in
the nucleus, bound to chromatin, and repress transcription. Upon phosphorylation, they …