EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells
DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including
homologous recombination (HR). While HR between identical sequences is robust in
mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair
(MMR) components such as MSH2. Exonuclease I (EXO1) interacts with the MMR
machinery and has been proposed to act downstream of the mismatch recognition proteins
in mismatch correction. EXO1 has also been shown to participate in extensive DSB end …
homologous recombination (HR). While HR between identical sequences is robust in
mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair
(MMR) components such as MSH2. Exonuclease I (EXO1) interacts with the MMR
machinery and has been proposed to act downstream of the mismatch recognition proteins
in mismatch correction. EXO1 has also been shown to participate in extensive DSB end …