Phospholipase D enzymes facilitate IL-17-and TNFα-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF)
SC Friday, DA Fox - Immunology letters, 2016 - Elsevier
In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration
of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and
T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and
other proinflammatory mediators of joint destruction. PLD enzymes specifically cleave
phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Agonist-induced
PLD activation results in PA synthesis, which is thought to be involved in a variety of rapid …
of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and
T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and
other proinflammatory mediators of joint destruction. PLD enzymes specifically cleave
phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Agonist-induced
PLD activation results in PA synthesis, which is thought to be involved in a variety of rapid …