[HTML][HTML] Rictor undergoes glycogen synthase kinase 3 (GSK3)-dependent, FBXW7-mediated ubiquitination and proteasomal degradation
Rictor, an essential component of mTOR complex 2 (mTORC2), plays a pivotal role in
regulating mTOR signaling and other biological functions. Posttranslational regulation of
rictor (eg via degradation) and its underlying mechanism are largely undefined and thus are
the focus of this study. Chemical inhibition of the proteasome increased rictor ubiquitination
and levels. Consistently, inhibition of FBXW7 with various genetic means including
knockdown, knock-out, and enforced expression of a dominant-negative mutant inhibited …
regulating mTOR signaling and other biological functions. Posttranslational regulation of
rictor (eg via degradation) and its underlying mechanism are largely undefined and thus are
the focus of this study. Chemical inhibition of the proteasome increased rictor ubiquitination
and levels. Consistently, inhibition of FBXW7 with various genetic means including
knockdown, knock-out, and enforced expression of a dominant-negative mutant inhibited …