Transcriptional control of effector and memory CD8+ T cell differentiation

SM Kaech, W Cui - Nature Reviews Immunology, 2012 - nature.com
Nature Reviews Immunology, 2012nature.com
During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity.
These cells can vary in their phenotype, function and location, and in their long-term fate in
terms of their ability to populate the memory T cell pool. Over the past decade, the signalling
pathways and transcriptional programmes that regulate the formation of heterogeneous
populations of effector and memory CD8+ T cells have started to be characterized, and this …
Abstract
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.
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