Distinguishing between unipolar depression and bipolar depression: current and future clinical and neuroimaging perspectives
JRC de Almeida, ML Phillips - Biological psychiatry, 2013 - Elsevier
Differentiating bipolar disorder (BD) from recurrent unipolar depression (UD) is a major
clinical challenge. Main reasons for this include the higher prevalence of depressive relative
to hypo/manic symptoms during the course of BD illness and the high prevalence of
subthreshold manic symptoms in both BD and UD depression. Identifying objective markers
of BD might help improve accuracy in differentiating between BD and UD depression, to
ultimately optimize clinical and functional outcome for all depressed individuals. Yet, only …
clinical challenge. Main reasons for this include the higher prevalence of depressive relative
to hypo/manic symptoms during the course of BD illness and the high prevalence of
subthreshold manic symptoms in both BD and UD depression. Identifying objective markers
of BD might help improve accuracy in differentiating between BD and UD depression, to
ultimately optimize clinical and functional outcome for all depressed individuals. Yet, only …