An operant conditioning model combined with a chemogenetic approach to study the neurobiology of food addiction in mice
E Martín-García, L Domingo-Rodriguez… - Bio …, 2020 - bio-protocol.org
The study of food addiction comprises 3 hallmarks that include the persistence to response
without an outcome, the strong motivation for palatable food, and the loss of inhibitory
control over food intake that leads to compulsive behavior in addicted individuals. The
complex multifactorial nature of this disorder and the unknown neurobiological mechanistic
correlation explains the lack of effective treatments. Our operant conditioning model allows
deciphering why some individuals are vulnerable and develop food addiction while others …
without an outcome, the strong motivation for palatable food, and the loss of inhibitory
control over food intake that leads to compulsive behavior in addicted individuals. The
complex multifactorial nature of this disorder and the unknown neurobiological mechanistic
correlation explains the lack of effective treatments. Our operant conditioning model allows
deciphering why some individuals are vulnerable and develop food addiction while others …