[HTML][HTML] Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

M Van Splunter, E Van Hoffen… - Mucosal …, 2018 - Elsevier
Oral cholera vaccination is used to induce immune responses in the intestines to protect
against cholera infection. However, oral vaccination may also affect immune responses in
other mucosal tissues. To study this, tissue-specific homing potential and kinetics of B-cell
responses were characterized after oral cholera vaccination. Healthy adult volunteers
received two doses of Dukoral® and blood, saliva, nasal wash, and fecal samples were
collected over time to detect vaccine-specific antibodies. Additionally, homing potential of …