Abnormalities in the coronary circulation that occur as a consequence of cardiac hypertrophy

ML Marcus, S Koyanagi, DG Harrison, DB Doty… - The American journal of …, 1983 - Elsevier
Myocardial ischemia is frequently observed in patients with cardiac hypertrophy even when
the conduit coronary arteries are normal. Recent studies indicate that impaired coronary
reserve in hypertrophied hearts probably occurs because growth of the coronary bed does
not keep pace with increases in cardiac mass. The imbalance between vascular proliferation
and muscle growth is probably most severe when cardiac hypertrophy is produced by
pressure overload. Experimental studies also suggest that abnormalities intrinsic to pressure …